ZBTB16 and neoplasm: Besides, multivariate analysis using Cox model, including tumor size, TNM stage, lymph node metastasis, distant metastasis, and PLZF expression showed that only PLZF was an independent prognostic factor for OS in GBC patients (HR, 0.48; 95% CI, 0.28–0.83, P = 0.008, Table 2).