The KID functions of EGFR might be a critical survival node for cancers that overexpress wild-type EGFR as these cancers are innately resistant to EGFR TKIs, where the KID functions of EGFR are elevated due to overexpression, and for cancers that have acquired resistance to EGFR TKIs, where EGFR’s function has been shifted to its KID functions by TKIs. This evidence concerns the gene EGFR and cancer.