EGFR and cancer: EGFR TKIs often cause growth arrest associated with non-selective, pro-survival autophagy10–12; however, loss-of-EGFR protein leads to severe autophagic cell death that could be rescued by a kinase-dead EGFR7, which suggests that the tyrosine kinase-dependent (KD) function of EGFR predominantly regulates cell proliferation, whereas the KID function of EGFR has a major role in promoting cancer cell survival.