Surprisingly, the TACC3 inhibitor KHS10120 reduced not only wild-type TACC3 protein expression but also expression of the FGFR3-TACC3 fusion protein in FGFR3-TACC3 fusion-transfected cervical cancer cell lines, leading to suppression of phosphorylation of ERK and AKT (Fig. 5a). The gene discussed is AKT1; the disease is cervical carcinoma.