Compared to the FGFR inhibitor or TACC3 inhibitor alone, dual inhibition of FGFR and TACC3 demonstrated significant reduction of the FGFR3-TACC3 fusion protein and phosphorylation of ERK and AKT (Fig. 5c), leading to a synergistic suppression of cell proliferation in FGFR3-TACC3 fusion-transfected cervical cancer cells (Fig. 5d). The gene discussed is AKT1; the disease is cervical carcinoma.