Furthermore, the total SOD1 level in CSF of 15 sporadic ALS patients was not significantly increased compared with 6 age-matched controls (1.80 ± 1.36 in sporadic ALS versus 0.923 ± 0.455 in controls, p = 0.079) (Figure S6). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.