PIK3CB and acute myeloid leukemia: To further examine the inhibitory effect of CP-EPS8-NLS on downstream MAPK/Erk and PI3K/Akt signaling, we measured p-Akt, Akt, Erk, p-Erk, p-stat3, mTOR and p-mTOR protein expression in AML cell lines (U937, KG1α, TF1α and HL-60) after CP-EPS8-NLS treatment for 12 h.