No compelling evidence was observed among postmenopausal women for any associations between BMI at age 18 years or recent BMI and breast cancer overall or ER/PR/HER2-defined subtypes, except for a 1.5-fold increased risk of luminal-like subtype associated with recent BMI among postmenopausal women who had never used MHT. The gene discussed is PGR; the disease is breast carcinoma.