Age ≥ 70, coronary heart disease, cerebral infarction, need for NIMV, albumin < 30 g/dl, D-dimer > 2.0 μg/mL, PSI > 130, CURB-65 ≥ 3, APACHE-II ≥ 20 were recruited in multivariate analysis. Here, ALB is linked to brain infarction.