Our lab recently reported that knockdown of LSD2 expression attenuates global DNA methylation, and combined inhibition of LSD2 and DNA methyltransferase (DNMTs) derepressed heavily methylated and silenced tumor suppressor genes, such as SFRP1, SFRP2 and CDH1, that in turn enhanced apoptosis in breast cancer cells [7]. This evidence concerns the gene KDM1B and breast cancer.