In the present study, we employed the pharmacosynthetic DREADDs (designer receptors exclusively activated by designer drugs) technique to selectively stimulate kisspeptin neurones in the MePD of Kiss‐Cre male mice aiming to investigate whether endogenous MePD kisspeptin signalling potentiates a preference for oestrous female mice, in addition to regulating sexual behaviour, the anxiety response and social interaction. The gene discussed is KISS1; the disease is Anxiety.