However, the observation that dual inhibition of JAK signaling and mutant IDH2 function leads to further normalization of aberrant gene expression in JAK2/IDH2-mutant stem/progenitor cells suggests that there is interplay between JAK signaling and epigenetic regulation in driving aberrant gene expression in Jak2/Idh2-mutant MPN. The gene discussed is IDH2; the disease is myeloproliferative disorder.