All mice receiving WT P14 cells or successfully transduced P14 Prf−/− CD8 T cells eliminated the tumor, whereas in untreated Prf−/− mice or Prf−/− mice transplanted with untransduced P14 Prf−/− CD8 T cells, tumor growth exceeded set limits (10 mm) or erupted, and therefore mice were humanely culled (Fig 3, C). This evidence concerns the gene CD8A and neoplasm.