These outcomes also demonstrate that HO-1 inducers offer corollary application for prevention and treatment of other severe chronic diseases, including eye disease (Szabo et al. 2004; Varga et al. 2013), type 2 diabetes (Mahmoud et al. 2013), rheumatoid arthritis (Mahmoud et al. 2014), and osteoarthritis (Mahmoud et al. 2015). Here, HMOX1 is linked to osteoarthritis.