CCL2 and age-related macular degeneration: There have been conflicting reports between different studies, some suggesting that most of the previously described hallmark features of AMD in the CCL2−/− model can be explained by normal ageing.33 Others indicated that this model develops drusen and other features of AMD, such as the accumulation of lipofuscin in RPE cells, progressive outer retinal degeneration and geographic/RPE atrophy.34