Acetylation of non-histone proteins also occurs which can modulate multiple protein properties in the cytoplasm and nucleus of the cancer cell.10 These epigenetic-dependent and epigenetic-independent actions of HDAC inhibitors ultimately result in reduced tumor growth through inhibition of cell proliferation and metastasis, terminal differentiation, and apoptosis.11 Entinostat is not yet approved by regulatory agencies for any indication. The gene discussed is HDAC9; the disease is neoplasm.