Here, we have studied translational readthrough of nonsense mutant TP53 by aminoglycosides further and show that the proteasome inhibitor bortezomib as well as the p53-Mdm2 inhibitors nutlin-3a and MI-773 can enhance the levels of full-length p53 and potentiate tumor cell death upon treatment with aminoglycosides. This evidence concerns the gene TP53 and neoplasm.