NFE2L2 and breast carcinoma: There is evidence that cell resistance is correlated with Nrf2 expression.54 In particular, it is known that Nrf2 induced radioresistance.55 Moreover, Nrf2 overexpression enhanced resistance of cultured cells to cisplatin, DOX and etoposide.25 Accordingly, also resistance to tamoxifen in breast cancer patients was correlated with increased expression of both Nrf2 and other antioxidant proteins.56 Inversely, downregulation of Nrf2, caused by transfection of Nrf2 siRNA26 or by the inhibitor brusatol,38 enhanced drug susceptibility of tumour cells.