One study evaluated AEG expression, including AEG-1 and AEG-9 (a.k.a. calnexin), following HIV-1 infection or treatment with gp120 in astrocytes.46 Recently, we identified AEG-1 as a novel modulator of HIV-1-associated neuroinflammation and glutamate clearance in astrocytes, suggesting a significant role in HAND.20,21 Therefore, we investigated plausible AEG-1 contributions toward HIV-1/ART-induced ER stress in astrocytes. The gene discussed is ITIH4; the disease is HIV-1 infection.