A distant enhancer of the B-cell-specific TF PAX5 was recently found to be recurrently mutated in CLL and other leukemias with an effect on expression.12 Here we detect an overlapping TFP for RAD21, associated with the non-coding gene RP11-397D12.4, with four SNVs in both of CLL and BCL (q = 7.2 × 10−2; Fig. 3a, b). Here, TF is linked to B-cell chronic lymphocytic leukemia.