The best-studied example is the TERT promoter, with frequent mutations in melanoma and other cancer types that increase expression in cellular assays.8,9 A few other cases of non-coding drivers have been reported, including splice site mutations in TP53 and GATA3,10,11 as well as mutations in a distal PAX5 enhancer that affect expression.12 The gene discussed is PAX5; the disease is cancer.