TP53 and cancer: For protein-coding genes, TP53 and KRAS were independently found to be significant in both the exome and whole-genome data sets (Supplementary Tables 12 and 14), with nominal significance (p < 0.05) in a range of individual cancer types (Supplementary Fig. 7a, b, f, j) in line with the literature.56,57 In addition, NRXN1 was found significant in the exome set (q = 0.09), with nominal significance (p < 0.02) for the breast cancer, liver hepatocellular carcinoma (HCC), and thyroid cancer types (Supplementary Fig. 7c, d, e).