E-cadherin is a cell adhesion molecule, whose deficiency leads to a lack of distinction and invasion in different carcinomas.6,7 Moreover, over-expression of cyclin D1 and EGFR molecular markers is related to cancer and intensification of dysplasia, while over-expression of these markers increases the risk of cancer in premalignant lesions of the oral cavity.15 This evidence concerns the gene CDH1 and cancer.