Neuropsychological assessments in patients with AD sharing cerebrovascular events tend to show worse cognitive impairment than evaluations among those with “pure” AD.11,36 Thus, patients with multiple microbleeds having lower CSF amyloid-β and higher t-tau and p-tau exhibited worse performance on cognitive assessments for global functions (Mini-Mental State Examination), object naming (Visual Association Test), language (Verbal Fluency Test), and digit span (forward and backward) than those without microbleeds.37 This evidence concerns the gene MAPT and Cognitive impairment.