Three main antihypertensive subclasses have been associated with a beneficial effect on cognitive function beyond blood pressure reduction (calcium channel blockers, angiotensin converting enzyme inhibitor, angiotensin-AT1-receptor-blockers).39 Further long-term randomized trials, designed especially to assess a link between antihypertensive therapy and cognitive decline or dementia with cognition as the primary outcome are therefore needed. This evidence concerns the gene ACE and dementia.