Cognitive performance worsened in accordance with severity of hypertension with a statistical difference occurring mainly between the HTN-2 and normotension groups on both the MMSE (control: 28.0 ± 2.0; HTN-1: 27.4 ± 2.1 and HTN-2: 26.9 ± 2.1, p = 0.004) and MoCA (control: 25.6 ± 3.0; HTN-1: 24.9 ± 3.0 and HTN-2: 23.8 ± 3.3, p = 0.003).The same tendency was observed on the NPE tests. This evidence concerns the gene DOCK3 and hypertensive disorder.