Importantly, meta-analysis of microarray data from diffuse large B-cell lymphoma patients found that miR-155 expression correlated negatively with Bcl6 and Hdac4 expression, strongly supporting the role of the miR-155/Bcl6/Hdac4 pathway in the pathogenesis of human leukemias (107). This evidence concerns the gene HDAC4 and diffuse large B-cell lymphoma.