Since we separately demonstrated the ability of miR-146a-5p to regulate the expression of two of the key mediators of angiogenesis and death, EMMPRIN and iNOS, we now ask whether miR-146a-5p can serve as regulatory switch between apoptosis and angiogenesis through its simultaneous and opposite effects on iNOS and EMMPRIN expression in the tumor cell. The gene discussed is NOS2; the disease is neoplasm.