At 28 days after birth (P28), minor (~15%) but significant retina degeneration was observed in Cngb1−/− mice (Figures 1A,B) (12) and more than 1,000 genes were dysregulated (>1.5-fold dysregulated, p < 0.05, STab.1) as seen from Affymetrix gene chip arrays. This evidence concerns the gene CNGB1 and retinal degeneration.