The activation of NF-κB in microglia, as seen in our present RP mouse model, is often associated with the release of reactive oxygen species and proinflammatory cytokines (such as IL-1β, interferon-γ, and TNF-α) that can cause secondary neurotoxicity and neuronal cell death including the degeneration of photoreceptors (50). The gene discussed is TNF; the disease is retinitis pigmentosa 1.