Two months after the initiation of cetuximab-based therapy, a significantly decreased percentage of CD16+ lymphocytes, in addition to significantly decreased percentages of CD56+ and CD16+CD56+ lymphocytes in the pool of lymphocytes and in the overall white blood cell pool, were shown in the group of patients with metastatic colorectal cancer in comparison with those determined in healthy individuals (Table 2). Here, NCAM1 is linked to metastatic colorectal cancer.