Cetuximab specifically binds to the EGF receptor and prevents the binding of its ligands, EGF and TGF-α, and inhibits the activation of EGFR/PI3K/AKT/mTOR, EGFR/RAS/RAF/MAPK/ERK, and JAK/STAT signaling pathways in cancer cells, which further leads to G1 cell cycle arrest and the induction of apoptosis, as well as a decrease in the production of matrix metalloproteinases and vascular endothelial growth factor (2, 7, 8). The gene discussed is EGFR; the disease is cancer.