HCMV UL94 and integrin NAG-2 cross-reactive antibodies have been found in sera of SSc patients, which induce apoptosis of NAG-2-expressing endothelial cells (Lunardi et al., 2000), and are more prominent in severe forms of SSc (Namboodiri et al., 2004). The gene discussed is TSPAN4; the disease is systemic sclerosis.