EGF and central nervous system cancer: To further clarify the SCD1-mediated Akt signaling axis in TMZ-resistant glioma cells, we used the Akt activator, EGF, to activate Akt signaling (Zhou et al., 2012), and the Akt direct inhibitor (MK2206) and indirect inhibitor (LY294002) to inactivate Akt signaling (Xu et al., 2017).