LGR5 and neoplasm: Since we showed that Rimonabant reduces Lgr5 expression in HCT116, to evaluate if it could improve the anti-tumor effects of 5-Fluorouracil, one of the most used chemotherapeutics in CRC treatment, MTT assay was performed in HCT116 cells treated for 24 h with the compound used alone or combined with 5FU.