Of note, in DLD1 CRC cells, Rimonabant produced mitotic catastrophe and modulated the expression of Cyclin B1, PARP-1, Aurora B and phosphorylated p38/MAPK and Chk1, improving the efficacy of Oxaliplatin (Santoro et al., 2009; Gazzerro et al., 2010). The gene discussed is PARP1; the disease is colorectal carcinoma.