In CRC cells, agonists and antagonists of both cannabinoid receptors, CB1 and CB2, showed anti-tumor action through induction of cell death with different mechanisms ranging from apoptosis to mitotic catastrophe (Greenhough et al., 2007; Cianchi et al., 2008; Izzo et al., 2008; Santoro et al., 2009). The gene discussed is CNR1; the disease is colorectal carcinoma.