Malfunctions of Gpr56 can cause the neurodevelopmental disease polymicrogyria. In the brain it is predominantly expressed in neuronal progenitor cells (NPC) in regions of postnatal neurogenesis where it is involved in the control of brain convolution/patterning in the cerebral cortex in an integrin α3β1-dependent manner. Moreover, Gpr56 operates together with Gα13 in the Rho-mediated regulation of NPC adhesion/migration. Gα13 again is essential in integrin signaling. Here, RHO is linked to polymicrogyria.