SOD1 and neurodegenerative disease: Exosomes participate in the propagation of misfolded SOD1 and TDP-43 proteins (Nonaka et al., 2013; Grad et al., 2014), in aberrant phenotype of immune cells (Pinto et al., 2017) and could impair synaptic plasticity in neurodegenerative diseases (Wang et al., 2017).