In postmortem PD brain, reactive microglia immunopositive for MHC class II, ICAM-1 (CD54), LFA-1 (CD11a), CD68, TLR2, and displaying ameboid morphologies, were encountered among several regions comprising the substantia nigra, striatum and hippocampus of postmortem PD brains (Imamura et al., 2003; Doorn et al., 2014). This evidence concerns the gene TLR2 and Parkinson disease.