CNR1 and major depressive disorder: In addition, changes at rs1049353, rs806380, rs2180619, rs806379, rs12720071, rs2023239 and the haplotype rs6454674-rs806380-rs806377-rs1049353 in the cannabinoid receptor 1 gene (CNR1) and at rs2501431 in the cannabinoid receptor 2 gene (CNR2) were found to be associated with working memory dysfunction, enhanced impulsivity, neurocognitive impairments, anxiety disorder, and depression in cannabis users9–13.