For this reason, ADO now refers to what was previously described by Albers-Schönberg, and discovered to be a form of Chloride Channel 7 deficiency osteopetrosis stemming from a single- allele dominant negative mutation in the CLCN7 gene[11,21–22,49]. The gene discussed is CLCN7; the disease is hyperinsulinemic hypoglycemia, familial, 4.