To explore the significance of Noxa in cisplatin‐induced cell death in HNSCC, we first stably expressed the shRNA for Noxa or scrambled shRNA as control in HN8 (p53 deleted) and HN12 (p53 truncated and inactivated) cells (p53 expression is shown in Fig. S1) and then treated with cisplatin with the IC50 concentrations (50 μm for HN8 or 25 μm for HN12). This evidence concerns the gene PMAIP1 and head and neck squamous cell carcinoma.