We also show that the 3′-UTR CRP rs1130864 A allele carrier state is more prevalent among patients with rapid cycling, which is relevant since thyroid disorders and auto-immune abnormalities are associated with refractory forms of BD, in particular, rapid cycling (Chakrabarti 2011; Padmos et al. 2004), even though these two phenotypes were not correlated in our cohort. The gene discussed is CRP; the disease is thyroid gland disorder.