In contrast to a prior report suggesting the potential oncogenic properties of the viral genes K1, ORF74 and vIRF1, we detected very few reads for these genes (ranged from 1 to 8 reads) in tumor tissues, suggesting either a very limited role of these genes in KS neoplastic growth or that their function is only essential at a temporally earlier stage in tumor development [56]. This evidence concerns the gene KRT1 and neoplasm.