Similar to Fayoumi chickens at 2 dpi, the role of lipids/lipid rafts in the pathogenesis of influenza was predicted due to upregulation of RSAD2. In addition, “Granzyme A signaling” was predicted as a unique pathway because of unique upregulation of granzyme A (GZMA) in Leghorn chickens at 6 dpi (Table 3). The gene discussed is RSAD2; the disease is influenza.