Consistent with previous studies19,21, we found that the severity of pancreatic injury, including pancreatic edema, inflammation and vacuole accumulation, was obviously attenuated by GSK7975A (CRAC channel blocker), which further demonstrate that STIM1–Orai1-mediated SOCE plays an influential role in AP (data not shown). Here, ORAI1 is linked to alkaline phosphatase measurement.