SOX9 and central nervous system cancer: While multiple other genes were uniquely up- and down-regulated in the rat tumors (e.g. RET, SOX9), overall, the rat gliomas showed the smallest percentage of unique DEGs (only 7% of up-regulated DEGs, 9% of down-regulated DEGs), and the largest percent overlap with the common DEGs (32% of up-regulated DEGs, 34% of down-regulated DEGs).