While this manuscript was under preparation, SOF was shown to protect against ZIKV in immunocompetent mice treated with an anti-IFNAR1 blocking antibody and in neonatal Swiss mice12,13, However, the first model has major limitations, as 20% of untreated ZIKV-infected mice survived, questioning the utility and efficiency of interferon (IFN)-response depleted mice to test drugs against ZIKV infections. Here, IFNAR1 is linked to Zika virus infectious disease.