We found several dysregulated genes upon ZIKV infection: including but not limited to increased expression of CCL5, CXCL9, CXCL10, CXCL11, MAP2K3, IFNB1, ISG15, NLRP3 and decreased expression of IKBKB, IRAK1, PIN1, MYD88; this pattern of gene dysregulation in response to ZIKV infection serves as a biomarker, reversal of which would be a desirable attribute of efficacious therapy. This evidence concerns the gene ISG15 and Zika virus infectious disease.