Increased hepatitis indicators, including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, albumin, total bilirubin, and direct bilirubin, were more frequently observed in whole course of HBsAg-positive subjects (Supplementary Fig. 1a), in spite that they received anti-viral treatment before chemotherapy until 6 months after chemotherapy. Here, GGTLC1 is linked to Hepatitis.