Of note, doxycycline‐inducible expression of LGP2 did not block dsRNAi in an embryonic carcinoma cell line (F9) that was previously shown to efficiently process dsRNA into siRNAs whilst being refractory to activation of the IFN response (Fig EV6A and B; Billy et al, 2001). The gene discussed is DHX58; the disease is carcinoma.