To determine the impact of viral infection on the stability of the LGP2–Dicer complex, we expressed FLAG‐LGP2 in HEK293 cells and infected these with the single‐stranded positive‐strand RNA virus encephalomyocarditis virus (EMCV), a member of the picornaviridae that generates long dsRNA products that trigger type I IFN induction via MDA5 (Pichlmair et al, 2009). Here, DHX58 is linked to viral infectious disease.