UCP2 and obesity due to melanocortin 4 receptor deficiency: In proinflammatory M1 macrophages that accumulate in adipose tissue during obesity-linked metabolic diseases, UCP2 expression is blocked by adipocyte FA binding protein (FABP4/aP2), and the resulting release of redox signaling is involved in inflammasome activation and IL-1β secretion (161, 385).