The C-α group showed higher PRDM16 gene levels than the C group as well as the HF-α group exhibited higher PRDM16 gene levels than the HF group (+174% and +287%, P<0.005, Fig 6A), suggesting the presence of viable beige cells in the sWAT after PPAR-α treatment. This evidence concerns the gene PRDM16 and hydrops fetalis.