DHRS2 and pneumococcal meningitis: In Brazil, pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine vaccination with a 3+1 schedule was introduced in 2010, and evidence from before-and-after studies indicated decreases of 13–63% in pneumococcal meningitis and 55–77% in pneumococcal meningitis deaths in children aged <3 years.9