SEMA3D and thyroid gland carcinoma: In summary, we proposed a more multifaceted approach to construct ceRNAs network, and identified a set of crucial genes that could be used as biomarkers for thyroid carcinoma therapy, such as hsa-mir-375, AC012668.2, and SEMA3D. In the future, more attention should be paid to the construction of ceRNA networks and the validation of biomarkers or RNA competing endogenous interactions.