In the present study, we found that positive UTX expression was associated with better clinical outcomes in 106 patients with ESCC receiving esophagectomy and blockage of endogenous UTX by the siRNA approach led to an increase in cell proliferation and elevation of the BrdU incorporation ability in ESCC cells, suggesting that UTX acts a tumor suppressor in ESCC. This evidence concerns the gene KDM6A and neoplasm.