Given the many oncogenes or tumor suppressors linked to mTOR signaling, it is estimated that mTORC1 function might be hyperactivated in up to 70% of all human tumors; much less information is available for mTORC2, although its link to PI3K/Phosphatase and tensin homolog on chromosome 10 (PTEN) suggests that it is also activated in tumor cells [19,20]. This evidence concerns the gene PTEN and neoplasm.