AKT1 and cancer: For example, PI3K signaling promotes the activation of the pro-lipogenic factor Sterol Regulatory Element-Binding Protein 1 (SRE-BP1), a key transcriptional factor that controls lipogenesis and lipid uptake, through AKT activation in a manner dependent on mTORC1 and lipid synthesis is a hallmark of proliferating cancer cells [89,135].