As mTORC1 activation increases HIF-1 α levels, by stimulating the translation of its mRNA, rapamycin downregulates several HIF transcriptional targets, such as VEGF, Platelet-Derived Growth Factor (PDGF), basic Fibroblast Growth Factor (bFGF) and other growth factors involved in angiogenesis and tumor progression [156]. Here, FGF2 is linked to neoplasm.