TP53 and cancer: Goudarzi and collaborators have investigated the outcomes of simultaneous inhibition of mTOR and activation of p53 by nucleolar stress, which is triggered by chemotherapeutic drugs: they demonstrated that rapamycin increased the levels of endogenous Mdm2 despite inhibition of its phosphorylation at Ser166, underlying the complexity of the interplay between p53 and mTOR in cancer [102].