TP53 and neoplasm: Autophagy, in turn, may have a dual role in tumor development: indeed, in a recent study by Rosenfeldt et al. in a transgenic model of Pancreatic Ductal Adenoma Carcinoma (PDAC), inhibition of autophagy blocked the progression of low-grade pancreatic intraepithelial neoplastic lesions to high-grade precancerous lesions and frank cancer in mice with wild-type p53, whereas its inhibition in the presence of p53 mutations promoted cancer formation [142,143].