Frequently occurring mutations that activate the PI3K-AKT pathway in cancer include AKT mutation and amplification, PIK3CA-activating mutations and gene amplification, and growth factor receptors amplification (i.e., Epidermal Growth Factor Receptor (EGFR), Insulin Growth Factor Receptor (IGFR), IRS) [50,124,125]. The gene discussed is EGFR; the disease is cancer.