PIK3R1 and Hyperglycemia: Moreover, gene expression of phosphoinositide-3-kinase, regulatory subunit 1 (PI3KR1) which is a PI3K/Akt signaling molecule, was increased at 12 h CoCl2 with euglycemia to 1.9-fold (p = 2.25 × 10−7) and hyperglycemia to 1.7-fold (p = 7.37 × 10−6).