MMP16 and Hyperglycemia: Microarray data showed that metformin, under hyperglycemia-CoCl2 at 12 h of CoCl2, significantly upregulated chemokine (C-X-C Motif) ligand 8 (CXCL8) to 1.9-fold (p = 2.84 × 10−2), lymphocyte antigen 96 (LY96) to 1.6-fold (p = 2.01 × 10−3), MMP16 to 1.7-fold (p = 2.34 × 10−2), and Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) to 2.7-fold (p = 1.15 × 10−2) that are known to enhance cell migration.