Metformin increased the expression of VEGFR1 and VEGFR2 only under hyperglycemia-CoCl2 at 3 h of CoCl2 (1.5-fold, p = 0.02 and 1.4-fold, p = 0.02 respectively (Figures S4 and S5)). This evidence concerns the gene KDR and Hyperglycemia.