TFPI2 and Hyperglycemia: Furthermore, metformin led to a significant overexpression of tissue factor pathway inhibitor 2 (TFPI2), a regulator of EC migration [6], to 1.6-fold (p = 2.07 × 10−4) under hyperglycemia-CoCl2 at 12 h of CoCl2.Whilst, this effect was not observed without metformin leading to downregulation of LY96 to −1.7-fold (p = 5.4 × 10−4), and TFPI2 to −1.7-fold (p = 1.4 × 10−5).