MAP2K1 and Hyperglycemia: Among these genes was the mitogen-activated protein kinase kinase 1 (MAP2K1), a key molecule in the ERK1/2 MAP kinase pathway, with 1.7-fold (p = 5.37 × 10−9) upregulated under euglycemia-CoCl2, and 1.6-fold (p = 6.8 × 10−8) upregulated under hyperglycemia-CoCl2.