The first ISAC microarray has enabled serum IgE testing on 94 allergens32, 33; the next‐generation microarray ISAC112 extended to 112 molecules is applied in today′s daily allergy diagnosis.28 Recently, an experimental ISAC format comprising 176 allergen molecules has been used in the European Union‐funded research project MeDALL to determine IgE sensitizations in birth cohorts.34 Allergen chip‐based diagnostic tools allow a risk evaluation for the grade of allergic reaction to be expected by providing individual IgE sensitization profiles. The gene discussed is IGHE; the disease is allergic disease.